pulmonary wedge pressure falls before 12

Exercise stress echocardiography of the pulmonary circulation: limits of normal and gender differences. The Journal of Physiology © 2016 The Physiological Society.Īrgiento P, Vanderpool RR, Mule M, Russo MG, D'Alto M, Bossone E, Chesler NC & Naeije R (2012). Changes in RpCp-time, PASP, PADP and mPAP were systematically related to increases in PAWP. In healthy adults, exercise is associated with decreases in Cp and a resultant decline in RpCp-time, indicating increased pulsatile right ventricular afterload.

Changes in PASP (r(2) = 0.43, P < 0.001), PADP (r(2) = 0.47, P < 0.001) and mPAP (r(2) = 0.50, P < 0.001) were linearly correlated with changes in PAWP, although they were not significantly related to changes in cardiac output. RpCp-time decreased for Light exercise (0.39 ± 0.08 to 0.25 ± 0.08, P < 0.001) without any further change for Moderate exercise, and the decrease in RpCp-time was related to changes in PAWP (r(2) = 0.26, P < 0.001). PASP, PADP, mPAP and PAWP increased for Light exercise, without any further rise for Moderate exercise. Cardiac output increased progressively during exercise. Measurements were made at rest and during two consecutive 8-10 min stages of cycle ergometry, at targeted heart-rates of 100 beats min(-1) (Light) and 120 beats min(-1) (Moderate). We examined the effect of exercise in 28 healthy non-athletic adults (55 ± 6 years) who underwent right heart catheterization to assess haemodynamics and calculate Rp and Cp. Identifying the determinants of RpCp-time should improve our understanding of the physiological behaviour of pulmonary arterial systolic (PASP), diastolic (PADP) and mean (mPAP) pressures in response to perturbations. The RpCp-time exhibits a narrow range, although it may be altered by the pulmonary artery wedge pressure (PAWP). The resistive and pulsatile components of right ventricular afterload (pulmonary vascular resistance, Rp compliance, Cp) are related by an inverse hyperbolic function, expressed as their product known as RpCp-time. Increases in PAWP in the setting of exercise are directly related to a decrease in pulmonary vascular compliance, despite small decreases in pulmonary vascular resistance, thereby increasing the pulsatile afterload to the right ventricle.

Pulmonary artery systolic, diastolic and mean pressures maintain a consistent relationship with one another, increasing linearly with increasing PAWP. We show that, in healthy exercising human adults, both pulmonary vascular resistance and compliance decrease in relation to exercise-associated increases in PAWP. This relationship predicts that pulmonary artery systolic, diastolic and mean pressure maintain a consistent relationship relative to the PAWP. A consistent inverse hyperbolic relationship has been observed between pulmonary vascular resistance and compliance, although changes in pulmonary artery wedge pressure (PAWP) may modify this relationship.

Pulmonary wedge pressure falls before 12